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Jun 13, - Symptoms of secondary syphilis include skin rash, swollen lymph nodes, and fever. The signs and symptoms of primary and secondary syphilis can be mild, and they might not be noticed. During the latent stage, there are no signs or symptoms. Tertiary syphilis is associated with severe medical problems.‎STD Facts - Syphilis (Detailed) · ‎Syphilis - Images · ‎Congenital Syphilis. Other symptoms of secondary stage syphilis include: fever. swollen lymph glands. sore throat. patchy hair loss. headaches. weight loss. muscle aches. fatigue.