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The exact causes of anencephaly are unknown. A lack of folic acid (vitamin B9) before and during pregnancy may increase the chance of neural tube defects, such as anencephaly or spina bifida (a birth defect in which the spine is exposed). Aug 2, - Anencephaly is a serious birth defect in which a baby is born without parts of the brain and skull. It is a type of neural tube defect (NTD). As the neural tube forms and closes, it helps form the baby's brain and skull (upper part of the neural tube), spinal cord, and back bones (lower part of the neural tube).